Cooperative Coinfection Dynamics
Chen Li and Dirk Brockmann, Robert Koch-Institute and Humboldt Universität zu Berlin, Berlin, Germany
Clicking on the central button starts/stops the simulation. The menu on the right selects different initial conditions. The menu on the left selects different reproduction ratios R0 and cooperativity coefficients C. Each node can acquire two infections (blue and red). A node that is infected by both, A and B is colored black, fully susceptible nodes are white. Transmissions occur among nearest neighbors only. When C > 1 one can observe a bi-stable equilibrium, when initially only few nodes are infected, the system will equilibrate to the disease free state. When initially a large fraction of the population is infected, cooperative coinfection can sustain an endemic state. Try the following combinations cooperative coinfection (R0 < 1, C > 1) with regional uniform infection (gap) compared to cooperative coinfection (R0 < 1, C > 1) with regional uniform infection (no gap) to see the key effect of cooperative coinfection or change the level of cooperativity when the system has equilibrated.