Cooperative Coinfection Dynamics

Chen Li and Dirk Brockmann, Robert Koch-Institute and Humboldt Universität zu Berlin, Berlin, Germany

Clicking on the central button starts/stops the simulation. The menu on the right selects different initial conditions. The menu on the left selects different **reproduction ratios R0** and **cooperativity coefficients C**. Each node can acquire two infections (blue and red). A node that is infected by both, A and B is colored black, fully susceptible nodes are white. Transmissions occur among nearest neighbors only. When C > 1 one can observe a bi-stable equilibrium, when initially only few nodes are infected, the system will equilibrate to the disease free state. When initially a large fraction of the population is infected, cooperative coinfection can sustain an endemic state. Try the following combinations **cooperative coinfection (R0 < 1, C > 1) with regional uniform infection (gap)** compared to **cooperative coinfection (R0 < 1, C > 1) with regional uniform infection (no gap)** to see the key effect of cooperative coinfection or change the level of cooperativity when the system has equilibrated.

See also: http://arxiv.org/abs/1603.09082